Recall 1:
A case of scleroderma. Which antibody is specific for lung disease?
A. Anti-RNP
B. Anti-Topoisomerase (Scl-70)
C. Anti-Polymerase III
Answer: B. Anti-Topoisomerase (Scl-70)✔️
Recall 2:
A case with sclerodactyly, dysphagia, and pulmonary symptoms. What is the most specific antibody for this case?
A) Anti-ANA
B) Anti-Topoisomerase I
C) Anti-PM-Scl
D) Anti-RNA polymerase III
Answer: B. Anti-Topoisomerase I
Recall 3:
Q-Female with heartburn, dysphagia, telangiectasia, skin changes. Likely diagnosis is CREST. What is the most relevant antibody?
Q-Case of CREST. What is the antibody test?
A. Anti-Scl 70
B. Anti-centromere
C. ANA
Answer: B. Anti-centromere✔️
Recall 4:
Tight skin + esophageal symptoms. Diagnosis: Systemic sclerosis. Marker?
A. Anti-centromere
B. Anti-Scl-70
C. Anti-Topoisomerase
Answer: A. Anti-centromere✔️
Recall 5:
Patient with CREST. What is the most specific antibody?
A. ANA
B. Anti-Scl-70
C. Anti-centromere
Answer: C. Anti-centromere✔️
Recall 6:
What does S4 heart sound suggest in scleroderma?
A. Restrictive cardiomyopathy
B. Pulmonary hypertension
Answer: B. Pulmonary hypertension✔️
Recall 7:
Most common complication in scleroderma?
A. Renal crisis
B. Pulmonary hypertension
C. Raynaud’s
Answer: B. Pulmonary hypertension✔️
Recall 8:
Scleroderma – What is the rapid cause of death?
Answer: Pulmonary hypertension✔️
Recall 9:
Case of diffuse cutaneous systemic sclerosis. What is the most likely cause of death?
A) Pulmonary hypertension✔️
B) Renal crisis
C) Heart failure
Recall 10:
Systemic sclerosis + SOB. What test helps diagnosis?
A. CT Chest
B. Echocardiography
C. Pulmonary function test
Answer: B. Echocardiography (to assess pulmonary hypertension)✔️
Recall 11:
Scleroderma + hypertension. At risk of what complication?
Answer: Renal failure or scleroderma renal crisis✔️
Recall 12:
A patient with scleroderma renal crisis presents with hypertension (170/100 mmHg) and a positive SCL-70 antibody. What is the most appropriate treatment?
Right is ) ACE inhibitor ✔️
Overlap syndrome Q :
Recall 1:
A patient with long-standing Raynaud’s phenomenon now complains of arthralgia and arthritis in the hands and wrists. Examination shows mild sclerodactyly and difficulty in swallowing. Serology is positive for ANA. What is the most likely diagnosis?
A) Systemic sclerosis
B) Rheumatoid arthritis
C) CREST syndrome
D) Overlap syndrome ✔️
Recall 2:
Patient with Raynaud’s phenomenon develops sclerodactyly and dysphagia. Diagnosis?
A. Diffuse cutaneous systemic sclerosis (DCSS)
B. Limited cutaneous systemic sclerosis (LCSS – CREST)
C. Overlap syndrome✔️
D. Systemic sclerosis sine scleroderma
Recall 3:
-Raynaud’s , dysphasia both solid & liquid, sclerodactiy, Arthritis, Malar rash. Best DX? MCTD ( Overlap syndrome)✔️
Recall 4:
-Dysphagia, Rash, proximal myopathy. DX ? MCTD ( Overlap syndrome)✔️
